Enhancement of dissolution and bioavailability of Eprosartan mesylate by forming Nanosuspension

Abstract

Eprosartan mesylate (EM) is a poorly aqueous soluble drug belonging to BCS-class II suffers from low bioavailability Issues (13%). The present study involves an effort for improving dissolution and thus the bioavailability of EM using nanosuspension approach. And the Further Evaluation of solubility and dissolution were performed   using some analytical tools that are infrared spectroscopy, differential scanning calorimeter, X-ray diffraction study respectively. Where saturation solubility shows 20 fold increases in solubility when formulated as nanosuspension. So the nanosuspension prepared using SLS, PVPK-30 and pluronics F-68 showed improved dissolution. Hence Nanosuspension formulation capable sorted as a promising approach for improving the dissolution of Eprosartan mesylate.