Studies on Anti-HIV activity and Cytotoxicity of Wrightia tomentosa Leaf

Authors

  • Periyasamy Selvam Reghavendra Institute of Pharmaceutical Education and Research, Anantapur 515 721, AP
  • E De Clercq Rega Institute of Medical Research, Katholieke University, Leuven, Belgium

Keywords:

Wrightia tomentosa, anti-HIV activity, Indirubin, Cytotoxicity

Abstract

Wrightia tomentosa leaf extracts and its isolated compounds (isatin, indirubin and indigotin) have been studied for inhibition of HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected MT-4 cells (C-type Adult T Leukemia cells). All the extracts and isolated compounds exhibited cytotoxicity  in MT-4 cells (CC50: 8-117 μg/ml) and Indirubin  displayed  marked cytostatic  properties  in MT-4 cells (CC50:8.32±3.83 μg/ ml).

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Published

2012-12-20

Issue

Vol. 1 No. 1 (2012): 2012 Volume - 1 Issue - 1

Section

Articles