Development And Validation Of A Hplc Method For The Determination Of Antidiabetics (Canagliflozin And Metformin) In Api And Pharmaceutical Dosage

Authors

  • Ansari Abdul Mutalib
  • H. Parameshwar Omega College of Pharmacy, Edulabad, Ghatkesar, Affiliated to Osmania University, Hyderabad, Telangana.
  • A.V. Jithan Omega College of Pharmacy, Edulabad, Ghatkesar, Affiliated to Osmania University, Hyderabad, Telangana.
  • Sai Lakshmi Omega College of Pharmacy, Edulabad, Ghatkesar, Affiliated to Osmania University, Hyderabad, Telangana.
  • C.A Sri Ranjani
  • K. Sindoora Omega College of Pharmacy, Edulabad, Ghatkesar, Affiliated to Osmania University, Hyderabad, Telangana.

Keywords:

RP-HPLC, Canagliflozin, Metformin, method development, validation parameters

Abstract

A sensitive & selective stability indicting RP-HPLC method has been developed & validated for the analysis of Canagliflozin & Metformin API. Based on peak purity results, obtained from the analysis of samples using described method, it can be concluded that the absence of co-eluting peak along with the main peak of Canagliflozin & Metformin indicated that the developed method is specific for the estimation of Canagliflozin & Metformin. Further the proposed RP-HPLC method has excellent sensitivity, precision and reproducibility.

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Published

2022-05-23

Issue

Vol. 11 No. 2 (2022): 2022 Volume - 11 Issue - 2

Section

Articles